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RNAi Therapy

RNA interference (RNAi), the core technology enabling Curigin’s gene therapy development, is a naturally occurring phenomenon in which small interfering RNA (siRNA) can knockdown target gene expression in a sequence-specific manner. The siRNA interacts with an RNA-induced silencing complex (RISC) which binds to and eliminates messenger RNA (mRNA) complementary to the siRNA sequence.

New drugs developed by applying RNAi therapy have huge potential to treat ‘undruggable’ diseases that have targets which cannot be safely and effectively treated by general chemical and antibody drugs.

Further, as RNAi therapy does not directly modify intracellular genes, it is a growing area of interest by many biotechnology and pharmaceutical companies as a safe gene therapy system.